Help Bruce Willis to beat FTD

Bruce Willis should try to take zolpidem with BrainGlucose nightly at bedtime(HS), so that he can gradually regain his circadian cycle and improve his brain function. After his cycle stabilized for a while, he should try very slowly to reduce the amount of zolpidem.

Aducanumab for Alzheimer’s, really?

The FDA’s advisory board is considering to approve the Biogen’s Aducanumab for Alzheimer’s therapy, again, after years “reorganizing” the clinical data.

One says the possible mechanism is to help open the canal for garbage plaque to leave the brain, different from the other explanation such as of Eli Lily’s.

According to the prediction of Free Energy and Memory Protein Stability theory, just let the plaque proteins leave the brain, one can’t stop the memory protein loss. Thus Aducanumab will not stop the deterioration of early and middle stage Alzheimer’s disease.

Let’s see.

Why early and middle stage AD patients are not afford to wait?

Why early and middle stage AD patients are not afford to wait?

Not just because researches showed AD is caused by deprivation of glucose in brain (such as 1-31-2017 Temple Univ.), clinically many AD patients also show symptoms of overnight low glucose in brain: typically, nightmares, night sweats, and hallucinations. Especially during middle stage Alzheimer’s while some patients exhibit higher frequency of symptoms (about twice weekly). That period usually does not last very long ranging from a couple of months up to a year. Passing that critical period, those Alzheimer’s patients could advance to severe stage of AD, when patients typically lose their dignity and independence as described in Johns Hopkins Medicine ( The underlying cause is explained as recurrent severe deprivation of glucose in brain breaks down memory structures and diminish enzyme activities, which in return triggers hormonal rescue mechanism to stimulate liver to generate sudden over flow of glucose into brain. These lack of glucose then causing spike of glucose roller coaster may eventually “kills” the brain, and make higher glucose content in the end stage of AD.

Thus a smooth supply of glucose during late night sleep is very critical if you or your loved ones experience those symptoms, since important REM sleep cycles requires higher level energy supply in brain to support memory function during this period!